Development and clinical application of bioactive glass-based biomaterial

Abstract

In the recent year, bioceramic (BC) system’s biomaterials are becoming one of the essential items in Modern Endodontics outside of Japan. Therefore, the development, popularization, and expansion of the evidence-based BC system’s biomaterial obtained from the basic and clinical research is necessary in the country. The systematic development of BC system’s biomaterials needs to be approached in consideration of the continuity of the disease and the bonding and compatibility between each biomaterial in Systematic because the diseases and tissues targeted for the endodontic treatment are various. We focused bioactive glass (BG), one of confirmed bioceramics, and are promoting the development of BG-based biomaterial (BG Material) for the wound healing and regeneration of dentin・pulp complex and periapical tissue with dental affiliated company. In translational research about the development of BG Material, we pushed forward development to a quality control process of the last product after having shown the evidence by basic researches. The BG-based endodontic biomaterial, Nishika Canal Sealer BG multi (BG multi), has been developed for root canal obturated sealer in 2017 and is also being applied for pulp capping material from 2021. This review shows the characteristics and clinical results to reflect the results of basic researches about BG Material. Additionally, we give an outline about the development of BG-based regenerative endodontic scaffold and want to mention the preservation of the tooth.