ビタミンKの結核菌に及ぼす影響

抄録

Studying on the influence of Vitamin K₃ (2-Methyl-1.4-naphthoquinone) on tubercle bacilli in vitro and in vivo, the authors obtained the following results.
1) In Kirchiner's fluid media, Mycobacterium tuberculosis typus humanus and typus gallinaceus are not only strictly prohibited their growth, but also killed thoroughly by Vitamin K₃ in the dilution of 2X10^-4 and the former is also checked fairly in the dilution of 10^-5 but Myc. the. typus bovinus is killed iu 10^-4 and strongly suppressed in 2 x 10^-4.
2) On glycerine agar slants, containing Vitamin K3 in the dilution of 2X10^-7, typus humanus and typus gallinaceus are both remarkably accerated their growth.
3) The inhibitory and promoting influences, above mentioned, on tubercle bacilli by Vitamin K₃ are not able to be obviously observed on egg media such as Oka-Katakura's.
4) Subcutaneous injections of Vitamin K, daily 1.5-2.5mg during about 4 months, reveal some therapeutical effects against the experimental tuberculosis of guinea pigs.