EXPERIMENTAL CONSIDERATIONS MADE ON THE MECHANISM OF THE OPERATION OF STREPTOMYCIN

Abstract

Inhibition of exudation and quickening of the absorption of exudate have been accounted as characteristic tissue reactions of living body which followed the administration of streptomycin. While, on the other hand, depending on the stage of administration of streptomycin, atrophy of epithelioid cells, weakening of the encapsulation of caseous lesions or hyalin degeneration of tubercles may be observed. As to whether they are due to the strong influence on tubercle bacilli exerted by streptomycin or due to the changes produced in the reactivity of the tissue cell system of living body, there are many problems yet to be solved.