実験的結核症におけるEthambutol (Dextro-2, 2'-(Ethylenediimino)-di-1-butanol) ならびにHON (δ-Hydroxy-γ-Oxo-L-norvaline) の治療効果
1964 年 39 巻 2 号 p. 69-73
詳細
1964 年 39 巻 2 号 p. 69-73
Therapeutic effects of Ethambutol and HON on experimental mouse and guinea pig tuberculosis were examined in comparison with those of strepto mycin. In mice, the drug effectiveness was.evaluted both from the change of “per cent.survival”, of fatally infected animals (intravenously with the inoculum of.0.5 or 1mg of bovine.tubercle bacilli) and also from the inhibited multiplication of the bacilli in the spleen of the animals infected with a rather small size of inoculum. (0.001mg). Intraperitoneal or oral administration of the drugs was.started the next day of infection and continued for two to three weeks. In these experimental conditions, the daily dose of 4mg of Ethambutol (as racemic compound) exerted a remarkable therapeutic effect comparable to that of 1mg of streptomycin. However, 2mg or 5mg of HON exerted only a slight favourable effect, though it was reproducible and definite.
In 25 guinea pigs, infection was subcutaneously conducted with 0.1mg of the same strain as above, and treatment was started preconfirming the formation of advanced tuberculous lesions in 5 animals sac rificed 4 weeks after infection. Namely, the remain ing 2 Oanimals were divided into 4 groups of equal 5. Against these groups drug administration was made subcutaneously for 5 weeks with 40mg daily dose of HON, with 40mg daily dose of Ethambutol (racemic compound), or 20mg daily dose of streptomycin respectively. The last one group was left untreated. One week after the termination of treat ment, all the animals were sacrificed for comparative observation of gross lesions and for quantitative culture test of the bacillin in the spleen and the lungs. A marked therapeutic effect observed in the group treated with streptomycin, but the effect of Ethambutol was moderate and that of HON was slight.
