肺結核外来化学療法の効果と近接成績

抄録

Following the previous three reports, radiological aggravation during and after the cessation of ambulatory chemotherapy was studied on 4, 232 cases of pulmonary tuberculosis treated for longer than 6 months during the period from 1953 to 1961. Radiological aggravation was divided into the following 3 types, namely appearance of new foci, enlargement of existing lesions, and the both.
Ther esults were summarized as follows:
1. Aggravation during chemotherapy
Rate of aggravated cases during chemotherapy was 3.7% (117 cases out of 3, 205) among original treatment group and 4.0% (41 cases out of 1, 027) among retreatment group (Table 1). Among aggravated cases, appearance of new foci and enlargement were neary equal in number (Table 1). No significant correlation was observed between the type of aggravation and the type of lesion at the onset of chemotherapy (Table 2), between the type of aggravation and the period of aggravation (Table 2), and between the type of aggravation and chemotherapy regimen (Table 3).
2. Aggravatio n after cessation of chemotherapy
Rate of aggravation after cessation of chemotherapy was 8.6% (275 cases) in original treatment group and 13.7% (141 cases) in retreatment group (Table 1). Among aggravated cases, appearance of new foci was found more frequently than enlargement (Table 1). Among cases treated with short term chemotherapy within 18 months and among cases treated with SM twice a week combined with PAS or INH twice a week combined with PAS—irrespective of length of chemotherapy—, appearance of new foci was observed frequently than enlargement.