肺結核化学療法時における結核菌のTuberactinomycin-N,Viomycin, CapreomycinおよびLividomycin耐性の境界値
1975 年 50 巻 4-5 号 p. 123-130
詳細
1975 年 50 巻 4-5 号 p. 123-130
The present study was carried out in aids to determine critical concentrations for resistances to tuberactinomycin-N (TUM-N), viomycin (VM), capreomycin (CPM), and lividomycin (LVM) in patients treated with these agents and to clarify the cross-resistance-relationships among resistances to amirioglucoside-antibiotics including kanamycin (KM).
Hospitalized patients excreting tubercle bacilli in their sputum were the subjects of observations. The patients were treated with either TUM-N, VM, CPM, VM, LVM or KM. Although TUM-N was used in two ways, daily administration and intermittent administration, the other agents were used by intermittent administration, 1 g per day, three times weekly. Two other antituberculous agents were used in combination, to which tubercle bacilli of the patients already showed resistances. The duration of administration of these aminoglucoside-antibiotics was usually 6 months, but KM was used often for one year or more. The resistances of tubercle bacilli to these agents were measured, as a rule, monthly.
