正常人T細胞のE-rosette形成能に及ぼす肺結核患者血清の抑制作用

抄録

The inhibitory effect of the serum from 14 patients with pulmonary tuberculosis on the E-rosette formation of normal donor T-cell was studied. The results obtained were as follows:
1. Some of the serum from patients with pulmonary tuberculosis inhibited the E-rosette forma tion of the normal T-cells, when compared with the serum from normal subjects. Five of 14 cases used in this study showed the increased inhibitory rate of more than 10 percent, and observing by the type of lesions, 4 of 7 cases with F type and one of 7 cases with C type of GAKKEN classification showed increased inhibitory rate. The mean of the inhibitory rate was 8±2 percent in the serum of F type and 2±1 percent in those of C, type, respectively. Thus, the serum from F type showed more inhibitory effect than those of C type.
2. The serum from a case with F type which showed high inhibitory effect was fractionated into euglobulin, pseudoglobulin and albumin fractions by the ammonium sulfate saturation method, and the inhibitory effect of each fraction was studied. The inhibitory effect was found in the non-γ-globulin fractions of pseudoglobulin and albumin, but not in the euglobulin fraction.