ガス曝露下における結核化学療法剤の効果に関する実験的研究

第3編薬剤耐性獲得について

抄録

In the previous reports, unfavourable conditions for the growth of tubercle bacilli were prepared by replacing air with various other gases using Kirchner's medium containing various drugs, and the bacteriostatic and bactericidal effects of anti-tuberculous agents were investigated.
In this report, the development of drug resistance of M. tuberculosis which was not killed by the bactericidal tests was investigated.
The development of drug resistance was not observed, regardless of the duration of drug contact with bacilli and of exposure to several kinds of gases.