PZAによる関節痛と高尿酸血症

抄録

Eighty four pulmonary tuberculosis patients who were admitted to the National Tokyo Chest Hospital and were treated originally by daily administration of INH, RFP and PZA between June1979 and July 1980 were subjected to the study. PZA were given in 35 cases for 2 months and in 49patients for 6 months. PZA dosage was 1.5 gram for patients weighing 45 kilogram and over.
1) Serum uric acid level: All the patients who received PZA showed the increased serum uricacid level, and in 75 patients (90%) the increase was two times of the value before treatment. Patientsshowing uric acid level more than 10 mg/dl were 30 (85.7%) out of 35 patients who received daily 2months PZA and 30 (62.5%) out of 48 patients who received daily 6 months PZA.
2) Arthralgia: Arthralgia was observed in 5 (14.3%) out of 35 patients who received daily 2months PZA and in 11 (22.4%) out of 49 patients who received daily 6 months PZA.
Soon after stopping PZA, serum uric acid level returned to normal and arthralgia disappearedand the re-administration of PZA was possible without or with slight arthralgia. Arthralgia inducedby PZA was related to daily drug dosage and duration of PZA administration, but not to serum uricacid level. The author would like to emphasize: “Do not stop PZA because of hyperuricemia andarthralgia!”