PZAを加えた初期強化短期化学療法
1986 年 61 巻 7 号 p. 363-369
詳細
1986 年 61 巻 7 号 p. 363-369
148 pulmonary tuberculosis patients without previous chemotherapy were treated by the regimen that included 2 months of SM (or EB), INH, RFP and PZA, followed by EB, INH and RFP. Drug dosage was INH 0.3g, RFP 0.45g, PZA 1.0-1.5g, SM 0.75-1.0g and EB 0.75-1.0g respectively. The chemotherapy was administered for 6 months after negative conversion of sputum by culture. Patients were followed up for 12 months after the cessation of chemotherapy.
The rate of negative conversion by culture was 79.7% at the 2nd month and 100% at the 6th month. It seemed that this result was almost similar to those in the previous trials of the short-ourse chemotherapy of the 19 · 20th A, 21st and 22nd series. Out of 47 cases who were followed up for more than 12 months after stopping chemotherapy, one case with single isolation of tubercle bacilli was observed. The incidence of adverse reactions induced by PZA was 24.4%.
