A 33-year-old female suffering from pulmonary tuberculosis was treated with Rifampicin and INH.
After a few days she felt bad, so she stopped by herself to take RFP and INH.
Seven days later she again took INH, and had no side effects. However, the next morningbefore breakfast she took 450 mg RFP and in half an hour, she had nausea, vomiting, dyspnea and fever. Therefore, she was admitted to our hospital.
On admission, her bloodpressure was 60/30 mmHg. pale edematous face, tachypnea, andpulse rate was 120/min.
Chest X-ray showed small patchy shadow at left subclavicral area and a chest physicalexamination showed nothing particularly wrong. A bloodtest showed a little pancytopenia BRC 332-104, Hb. 9.8 g/dl, Ht. 29.5%, platelet 12.6-10 4, liver function; GOT 46, GPT 19, increaced serum bilirubin to 1.38 mg/dl; and bloodgasanalysis: Pa O2 48.7 Torr, Pa CO229. 4 Torr, pH 7.12; hypoxemia and acidosis.
The patient was treated with a vasopressor by continuous drop infusion with diuretic and oxygen inhalation.
Twelve days after the biginning of the disease the anaphylaxic shock was ceased andthe recovery of the patient was swift and remarkable, and she was then discharged.
