Mycobacterium avium Complex Mycobacterium fortuitum及びMycobacterium chelonaeの抗結核剤感受性の比較
キーワード:
抗結核剤感受性
1988 年 63 巻 8 号 p. 563-568
詳細
1988 年 63 巻 8 号 p. 563-568
The multiple drug-resistance of Mycobacterium avium complex strains which were not exposed to antituberculosis drugs was compared with that of Mycobacterium fortuitum and Mycobacterium chelonae strains which were also not exposed previously to antituberculosis drugs.The number of strains in this study were 55, 20 and 20, respectively, and the Ogawaegg medium was used in the drug susceptibility testings.
The distribution curves of minimal inhibitory concentrations of rifampicin, minocycline and kitasamycin for the M.avium complex strains were bimodal and the strains were divided into two groups, one naturally highly resistant and another relatively susceptible. The susceptibility to rifampicin was correlated to the susceptibility to minocycline and to the susceptibility to kitasamycin (Tables 1 and 2).The susceptibility of the naturally resistant group of the M.avium complex strains to rifampicin, minocycline and kitasamycin were almost similar to the susceptibility of M.fortuitum and M.chelonae strains to these drugs.
M.fortuitum and M.chelonae strains were more resistant than M.avium complex strains in respect to the susceptibility to most drugs except ethionamide.
The susceptibility to rifampicin of the susceptible group of the M.avium complex was almost equal to that of Mycobacterium tuberculosis strains.This finding suggests that rifampicin may be useful in the treatment of infection due to rifampicin-susceptible strains of the M.avium complex.Furthermore, it was shown also that the susceptibilities to enviomycin and kanamycin of the M.avium complex strains are not so markedly different from those of M.tuberculosis strains.This suggests that these drugs may, to some extent, be useful in the treatment.
