We experienced adverse reactions to antituberculous agents in 17 patients (53%) out of 32 patients treated for tuberculosis and nontuberculous pulmonary mycobacteriosis.
Side effects were seen in 15 patients (47%), and abnormal laboratory findings were observed in 9 patients (28%). Most side effects mostly appeared within two weeks after theadministration, and were of short duration. However, there were also side effects such asneurological symptoms, arthralgia, and general fatigue which appeared after one monthand lasted for a long duration. These results suggest that careful observation for adversereactions in antituberculous treatment is required. Finally, 11 patients with adverse reactionswere successfully treated by changing antituberculous agents or readministrationafter temporary stop of the administration. Four patients improved even with continueduse of agents causing side-effects. However, in the case of two patients who had tochange antituberculous agents, adverse reactions to all antituberculous agents appearedand the treatment for tuberculosis and nontuberculous pulmonary mycobacteriosis had tobe stopped.
