2022 Volume 57 Issue 3 Pages 108-112
In recent years, the resolution of protein structural analysis by cryo-EM was dramatically improved, due to the using a new type of camera that can detect electrons directly named direct electron detection camera, and it is now possible to construct an atomic model using only cryo-EM structural analysis. It is now the first choice for structural analysis of protein molecules with molecular weights exceeding 300 kDa, and has now established itself as a powerful tool for structural analysis. In order to make this technology available to as many researchers as possible, cryo-EM facilities for shared use have been established around the world. In Japan, 19 cryo-EMs at 9 facilities are in operation, and anyone can easily receive support for their use through the Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS). This review introduce of the flow of establishment of joint-use facilities in Japan, and discusses the current issues, and future prospects.
