胃に原発した絨毛癌の免疫組織化学ならびに電子顕微鏡による研究

抄録

Choriocarcinoma commonly springs from the chorionic epithelial cells of the placenta, and it sometimes occurs in the germ cells of the ovary and testis, and the pineal region, the mediastinum, and the retroperitoreum. However, this carcinoma of the stomach origin has scarcely been reported. The present paper reports a case of the choriocarcinoma of the stomach origin. Here we investigated immunohistochemically the localization of three main marker of the embryonic carcinoma, human chorionic gonadotropin (hCG), carcino embryonic antigen (CEA), and α-fetoprotein (AFP). Moreover we examined the characterization of the cell structure by electoron microscopy. The hCG reaction of some syncytiotrophoblastic tumor cells and cytotrophoblast cells proved positive. This strongly suggested that these cells can produce the hCG. On the other hand, there was no cell showing the positive reaction against CEA and AFP. Two types of cells can be found under electron microscopy. One is a multinuclear syncytiotrophoblastic tumor cell and the other is a mononuclear cytotrophoblast with a small amount of organella. In the cytoplasm of both cells, the developed Rough Endoplasmic Reticulum exhibiting a string form were observed.