In this study, histopathological studies on helminthiasis of domestic animals in Southeast Asia and South America were performed. In fascioliasis, destructuring of liver and strong fibrinogenesis of interlobular connective tissues were found. Bile ducts were enlarged and swollen, and epithelial cell membranes in bile ducts were changed into intestinal epitherial cells (called metaplasia) that contained goblet cells and basal granular cells. These pathological features occurred in both Fasciola jaksoni and F. hepatica. In schistosomiasis, granulomas around eggs were found, and eggs were surrounded by multinucleic giant cells, where collagen fibers and inflammatory cells such as neutrophils , lymphocytes and plasma cells were infiltrated.