Synthesis and characterization of metal-included hemicryptophanes

Abstract

Molecular capsules which provide precise internal spaces have been created as the active site of the artificial enzyme. In this study, a zinc(II)-included hemicryptophane, which has a zinc(II) centre embedded in the cavity, was synthesized in high yield and characterized by ESI-MS, NMR spectroscopy, and X-ray crystal structure analysis. The X-ray crystal structure shows that zinc(II)-included hemicryptophane has a pre-organized cavity, formed by the cyclotriveratrylene (CTV) and tris(aminoethyl)amine (tren) moieties.