抄録
Thirteen patients with acute rheumatic fever in young adults and adults were treated with 3 g or 6 g of aspirin. Three grams of aspirin had a similar dramatic effect to the toxic symptoms of fever and arthralgia etc. as 6g of aspirin. However, for the improvement of acute phase reactants, 6 g was definitely superior to 3g.
Based on the study of the change of Urinary 17-KS and circulating eosino-phils counts, such differences were assumed that 6 g of aspirin seemed to have non-specific ACTH-like effects other than the specific pharmacological effects of aspirin. These ACTH-like effects were not proved from the point of carbohydrate metabolism. The disturbances of atrio-ventricular conduction were improved by aspirin. Side effects of aspirin were found in two-thirds of the cases. Chondroitin sulfate tolerance test was reported as an index of cessation for anti inflammatory drugs.
