LOCAL PATHOLOGICAL CHANGES FOLLOWING INJECTION OF HEAT-STABLE SUBSTANCES IN THE HABU-SNAKE (TRIMERESURUS FLAVOV IRIDIS) VENOM

Abstract

An injection of Habu-snake venom, heated for 10 minutes at 100°C., caused myolysis at the site, histologically. But different from crude venom action, no hemorrhagic changes were recognized. At first, disappearance of mitchondria in the muscular fibers was seen, and then muscular splitting and lysis followed.
While the myolytic changes caused by crude venom began immediately af ter the injection, the beginning of the changes were delayed when the heated material were used.
Anti-Habu-serum neutralised the toxicity of the heated venom, and also, E.D.T.A.-Ca, Cocarboxylase and α-Thiolactoylglicine-Na repressed the toxicity in vitro.