Abstract
1. As a new method for screening studies of psychotropic substances, simplification of the “cloister method” was attempted, and recently accomplished.
2. A relay circuit which estimates “a ratio of cyclic walk (R%)” was added to the original method.
3. Using this method, effects of Methamphetamine and a derivative of diphenylpropenylamine (HK-2600) on mice behavior were tested.
4. Increased spontaneous activity was observed in both groups of mice but those treated with Methamphetamine behaved in a very different way when measured by the R%.Mice treated with Methamphetamine showed a high rate of R% (80100%). On the contrary, mice treated with HK-2600 showed various values resembling saline controls.
5. This new method was discussed from a statistical point of view and admitted as a suitable and effective method for estimations the effects of central excitant drugs.
