Since 1964, the author has investigated frequency, cause and medical treatment of low back pain in a rural village of Gunma prefecture. Further he observed, from sociological viewpoint, influence of low back pain on zeal of rural workers for production, and made epibemiological study on it.
The 1st report gives the preliminary approach to the question-collection of data from 1, 422 inhabitants of both sexes by enquete on frequency, mode of development, condition and cause of low back pain. The 2 nd report gives X-ray observations of 274 inhabitants of both sexes with low back pain and obstructions in their everyday lives in thrms of work day loss and medical treatments, which are used for the assessment of their disability. It was clarified by the preliminary approach given in the 1st report that a considerable large proportion, 23.5% mentioned “coldness” as the cause of low back pain, and that it developed in winter twice as often as in summer. In view of this local skin temperature was measured with a thermistor in order to seek relation between indivedual reactivity against exposure to coldness and incidence rate of low back pain. In addition, the subjects were exposed to artificial coldness to observe their reactions. These are the contents of the 5rd report. The results are summarized as follows :
1. The frequency of low back pain tended to increase with aging in both sexes. Actually suffering cases (those who have developed low back pain in the past 1 year) account for 15.3% and those who have its history, 42.0%. It needs much precaution to determine the frequency, since low back pain is variable in its nature, its manifestation is subjective, and its definition is not yet established.
2. To the question 'when does the pain develop', the greatest number, 32%, responded, 'Always', followed by 19, 8% of 'Before going to bed', 13.4% of 'While walking', and 12% 'Abruptly'.
3. As for the subjective cause and evoking factor 'not clear' represents 26. 1%, 'agricultural work' 25.3%, 'coldness' 25.5%, and 'trauma' relatively low 17. 7%.
4. Disability owing to low back pain generally occurred in higher frequency in advanced ages and in females. High grade disability however, occurred also in thirties in both sexes.
5. X-ray observation revealed spondylosis deformans in 44. 8% and osteoporosis in 23. 7%. Discopathy such as herniation of nucleus pulposus was relatively infrequent, Bone abnormality was absent in 17.3% of males and 29.4% of females. The X-ray findings were not always in agreement with the symptoms.
6. As for the duration of the pain, 'within I week' accounted for 1/3 for both males and females. Considerably large proportions, 45% of males and 35% of females, complained of the pain more than 30 days in total in a year.
7. about 37% received medical treatment, and the remainder were either imperfectly treated or untreated.
8. More females than males complained of coldness; especially remarkable are714%of female in thirties and forties and 51.0% in fifties, who complained of coldness. Low back pain occurred more frequently in those who complained of coldness without regard to sex.
9. Experiment on exposure to coldness (examination for rise in skin temperature on exposure to artificial coldness). Restoration of skin temperature was slow in those with objective symptoms such as tender point, , back pain, myosclerosis and lasegue.
10. In relatively younger subjects who were actually suffering low back pain, skin temperature (on the hip) was lower than in the normal by 0. 1°0. 4°C.
In the village of the present survey, there were many with the socalled lumdago, which is. induced by overwork in agriculture or by coldness. In those of advanced age were observed also spondylosis deformans and osteoporosis which result from physiological aging accelerated by overwork which is postulated as the result of enlargement of occupational sphere.

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Effects of various pressor amines on coronary circulation in anesthetized dogs were studied by the use of electromagnetic flow meter and coronary artreiography,
1) Intravenous administration of adrenaline, noradrenaline or isoproterenol resulted in increase of coronary blood flow. By coronary arteriography, these substances were noted to have dilating effect on coronary arteries of visible diameter.
2) The increase of coronary blood flow was observed generally parallel to the rise of systemic blood pressure. However, in some instances, the increase of coronary blood flow continued even during the phase of the decreased blood pressure.
3) The administration of isoproterenol caused the increased coronary blood flow and, at the same time, the decreased systemic blood pressure.
4) The increase in coronary blood flow by these substances was inhibited by previous or concomitant administration of propranolol.
5) Intracoronary administration of small dosis of adrenaline, noradrenaline or isoproterenol resulted in the increase of the maximum flow of diastolic phase and decrease of the minimum flow of systolic phase. These changes in the coronary blood flow were more prominent than the changes by intravenous administration of these substances in the same order of doses which should be expected.
6) These results suggest that adrenaline, noradrenaline and isoproterenol may have the direct dilating effect on coronary artery.

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1. As a new method for screening studies of psychotropic substances, simplification of the “cloister method” was attempted, and recently accomplished.
2. A relay circuit which estimates “a ratio of cyclic walk (R%)” was added to the original method.
3. Using this method, effects of Methamphetamine and a derivative of diphenylpropenylamine (HK-2600) on mice behavior were tested.
4. Increased spontaneous activity was observed in both groups of mice but those treated with Methamphetamine behaved in a very different way when measured by the R%.Mice treated with Methamphetamine showed a high rate of R% (80100%). On the contrary, mice treated with HK-2600 showed various values resembling saline controls.
5. This new method was discussed from a statistical point of view and admitted as a suitable and effective method for estimations the effects of central excitant drugs.

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Both healthy and injured tibial tuberosities in the Osgood-Schlatter's disease were roentgenologically examined on the views of varing roentgenographic penetrations.
1 The small elevation of bone was seen in 35% of normal tibial surface above the tuberosity, and it tended to situate on the medial side of the sagittal plane which included in the center of the tuberosity.
2. In fresh cases of Osgood-Schlatter's disease, the lesions were almost localized in front of the epiphyseal beak and the extents could be divided into four groops.
3. The wide variant of deformity in the final stage of Osgood-Schlatter's disease were classified into four types (I a-b, II a-g, IIIa-c, IV) according to the Kikuchi's method which demonstrates the tuberosity exactly. The abnormal buttress of bone on the tibial surface above the tuberosity, one of the most characteristic featuress in the disease, were seen in 60% of the series. Theses buttress were situated just above or upper medial side of the tuberosities, and seemed to rise from normal elevation of bone. The proximal end of the tibial tuberosity was commonly lifted and in the highly deformed cases the buttress looked ass if to be a part of tuberosity as a result of the fusion with the tuberosity.

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During a peroid of 20 years up to the end of 1966, 20 Patients with tumors of the external auditory canal visited the Department of Oto-rhino-laryngology of the Gunma Univeristy. Cases of them were benign tumors. They were : each 2 cases of cerminoma and naevus pigmentosus, and each 1 case of melanoma, chondroma, osteoma, haemangioma, fibroma, cyst and osteoma. The other 9 cases were malignant tumors (8 cases were squamous cell carcinoma and 1 case was carcinoma simplex). 130 cases of benign tumors of the external auditory canal which had been reported in Japan were discussed with our 11 cases. Despite pathohistological benignity, some clinically manifested malignant features. It is therefore necessary in their treatment to grasp exactly the essential nature of each tumor. Benign tumors of the external auditory canal are not so rare as generally discribed in textbooks. Often they seem to be misdiagnosed as otofuruncle. To diagnosis of them, careful observation and repeated pathohistological examinations are necessary.

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The uptake of thymidine-H³ by human gastric cancer was studied in vitro, and the resulting labeling of cells was used as an indicator of the proliferative capacity of these tumors.
Superficial concaving type (IIc type) and mixed type (IIc + III, III + IIc type) of early gastric cancer from 7 patients, and Borrmann III type of advanced gastric cancer from 2 patients were studied.
Specimens of tumors were obtained either at the time of biopsy or excision. The specimens incubated for 2 hours at 37°C in a medium consisting of 5cc of human whole blood and 25μC of thymidine-H³. After the incubation, autoradiographs were prepared, and labeled tumor cells were counted on the autoradiographs.
All of the early gastric cancer showed a high number of labeled cells, the rate of labeled cells of total counted cells ranged from 13.4% to 27. 2% (average 22. 9%) In advanced gastric cancer, the percentage of in ranged from 10.3% to 23.4%.
The results of this study are suggested that the tumor cell proliferation of the early gastric cancer was as high as that of the advanced cancer.

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