Abstract
Thirteen patients with nephroblastoma, including one with unfavorable histology and one mesoblastic nephroma, were treated at Gunma University Hospital and Gunma Children's Hospital Medical Center between 1971 and December 1988. The ages of the patients, 6 boys and 7 girls, ranged from 3 months to 11 years (median 2 years). The stages were I in 4 patients, II in 2, III in 5, and IV and V in one patient each. Nephrectomy was done in 12 patients and rupture with tumor spillage was experienced in 3. Chemotherapy consisted of actinomycin D and vincristine before 1987. Radiation (16-40. 5Gy) was given in 11 patients. After 1987, postoperative therapy was performed according to the NWTS-2 regimen. At the time of evaluation, January 1992, 11 out of 13 patients survived without any evidence of disease. Complications of treatment included scoliosis of the spine, atrophy of the chest and abdominal wall and postoperative intestinal obstruction after nephrectomy. Recent advances in the understanding and management of nephroblastoma are discussed.
