Abstract
Hepatic changes in rabbits treated with repeated bloodletting were characterized in early stage by foamy swelling and vacuolation of the hepatic cells focal in distribution and necrosis in the central zone of the lobules. At advanced stage of anemia vacuolar or reticular appearance of the cells involved became cf severe degree, the nuclei and cytoplasmas tending to fade and loose their staining ability. Fat accumulation was observed fairy confined to the areas surrounding the cell group undergoing degeneration.
The mitochondria, of the hepatic cells showing degeneration were swollen, vacuolated with a positive reaction to osmic acid or obscured.
Hyperplasia of the marrow took place at the expence of the fat. The reduction of the fat tissue in the marrow seemed to be closely related to the appearance of fat embolism in the lnng.
Lipemia was observed about a week after the loss of blood from the body. Access of fat in the blood stream possibly caused by disturbances in functional activities of the hepatic cells due to anoxia or decrease in plasma protein and by mobilization of depot fat is probably an important resource of the fat accumulating hepatic cells.
At prolonged stage of anemia, there was a disappearance of extramedullary hematopoiesis in the liver, spleen and lymphnodes which was observed in early stage.
Hemosiderin deposition was not demonstrated in animals used in this experiment.
