STUDIES ON THE METABOLISM OF Zr95
1959 Volume 9 Issue 5 Pages 1139-1148
Details
1959 Volume 9 Issue 5 Pages 1139-1148
Male dd strain mice weighing about 20 g were Subcutaneously (and or intraperitoneally) injected with 1 μc/0.1cc of Zr95, and its excretion, distribution and effects of non radioactive Zr salt, Ca-EDTA, Na citrate, Na Ca citrate, BAL, MgSO4 and the starvation upon these were investigated with the following results :
1. In the beginning Zr 95 injected subcutaneously or intraperitoneally was found in a largest quantity in the blood, but it gradually became more concentrated in the bone.
2. The excretion of subcutaneously given Zr95 was highest on the first day-3.1 and 5.9% into urine and feces, respectively, and thereafter gradually declined. The total excretion in 4 days amounted to 16.2%. The excretion into feces was about 2 times that into urine. The distribution of Zr95 at 4th day of the administration was in the order of Bone (11.7%/g) Kidney Blood Liver.
3. When non-radioactive ZrOCl2 was given as carrier of Zr95, a smaller dose slightly accelerated the excretion, while a larger dose conversely inhibited it.
4. The excretion of Zr95 tended to increase on the administration of Ca EDTA, Na Ca citrate, but it tended to decrease on Na citrate, and it changed scarcely on BAL and MgSO4.
5. By the starvation, the excretion of Zr95 tended to decrease and the retention of it was increased in liver.
