側鎖結晶性ブロック共重合体を用いた動脈血管塞栓機能を有する熱レオロジー流体の創製と評価

抄録

We polymerized a hydrophilic side chain crystalline block copolymer (SCCBC) by nitroxide-mediated living radical polymerization. The polymerized SCCBC changed the surface of polyethylene (PE) to hydrophilic and enabled dispersing PE particles in a polar solution. In addition, the PE particle suspension behaved as thermal rheological fluid (TR fluid). By using the SCCBC, PE particle and contrast medium (as a solution), we prepared a new functional TR fluid as an artery embolization agent. This new functional TR fluid showed a transition temperature near the body temperature and changed to solid. Furthermore, this TR fluid could be injected into the renal artery of a rabbit under X-ray fluoroscopy and sustained embolization for 28 days. This result indicates that the TR fluid could be used as embolic or hemostatic agent.