自然発現唇顎口蓋裂マウスの顎顔面頭蓋の成長発育に関する研究
―二次口蓋形成後から出生直前まで―
1980 年 47 巻 2 号 p. 213-234
詳細
1980 年 47 巻 2 号 p. 213-234
The extent of the deformities in the craniof acial complex accompanied with cleft lip and palate and the subsequent changes in growth and development were studied. CL/Fr mouse fetuses with spontaneous cleft lip and palate were divided into the bilateral group (total 73 litters) and the unilateral group (total 57 litters) . The craniof acial complex of each group was compared with its respective normal littermates at 16. 5, 17.5 and 18.5 days of gestation by means of standardized roentogenocephalograms.
Results
1. The length of the anterior cranial base was significantly shorter in the bilateral group. A similar tendency was observed in the unilateral group.
2. In both cleft groups,
a. The cranial base angle was significantly greater at day 18.5.
b. Gradual downward displacement of the basisphenoid bone was the tendency.
c. The mandible was in the upper position.
d. The width at the most anterior part of the maxilla and bizygomatic width were significantly broader, while the width at the most constricted part of the frontal bone was significantly narrower.
e. The width of the dentofacial complex tends to expand in the lower frontal direction from the region around the lacrimal bone, and constricts in the upper posterior direction.
