抄録
In recent years, reserpine has been used extensively for the analyses of the action of adrenergic drugs. It is well known that reserpine interferes with the binding of catecholamines and depletes them from the storage sites of various organs. However, it has been clearly demonstrated that the reserpine administered intravenously in the anesthetized intact dogs does not produce changes in pressure or it produces a pronounced hypotension.In the present experiments, a prolonged and marked increase of blood pressure elicited by reserpine following the administrations of ephedrine or metamphetamine but not tyramine were recognized.These systemic arterial pressure changes by reserpine were analysed system-atically including the influences of blocking agents and attempts were made to elucidate the mechanism of reserpine and other adrenergic drugs.
