Abstract
The first distinctive epidemic of hand, foot and mouth disease was reported in 1957 in Toronto, Canada and Coxsackie virus group A type 16 was implicated.Robinson, Doane and Rhodes described an illness evidently due to an A 16 Coxsackie virus in which the febrile course was marked by oral blisters and a maculopapular rash of the hands and the feet that characteristically became vesicular and to which the name “hand, foot and mouth” disease is frequently applied.Type A16 is most common, but A5 and A10 have been reported occasionally.The following is a report of 14 cases of hand, foot and mouth disease studied in the summer of 1968.Coxsackie virus A16 was isolated from four patients, with suckling mice and established green monkey kidney cell culture and serum neutralizing antibody titers to this virus were demonstrated in seven tested cases.
