T-Lymphocyte Subsets in Human Non-Insulin-Dependent Diabetes Mellitus (Type II) Studied by Two-Color Flow Cytometry

抄録

We report the immunological characteristics of human penipheral T lymphocytes and behavior of PHA-stimulated lymphocytes in Type II diabetes mellitus, investigated two-color flow cytometry. The subsets of Leu11+Leu7+, Leu11-Leu7+ and Leu7+Leu2+ were decreased significantly in peripheral Natural Killer cells. After PHA stimulation the T-cell subsets demonstrated a decrease in the inducer subset and in the cytotoxic subset. The helper cell subset showed a negative regression with HbA₁. The cytotoxic cell subset showed a positive regression with HbA₁ and also FBS. The CD4/CD8 ratio, and the IL2+Leu2+subset, showed a negative regressions with HbA₁, and the diabetic duration, respectively. Thus, these results are afurther demonstration of changes in lymphocytes in NIDDM.