EXPERIMENTAL STUDIES ON EXCESSIVE INTAKE OF NaCl
I. THE EFFECT OF SALT WATER INTAKE ON THE GROWTH OF RAT
1962 年 9 巻 1 号 p. 40-51
詳細
1962 年 9 巻 1 号 p. 40-51
16 rats from two litters (8 male and 8 female) were administered 1 %, 2 % and 3 % of salt water freely, starting at the latter part of puberty (the 60th day after birth) and early part of growth completion (the 120th day after birth). The effect of salt water intake on the growth of those rats in the two different growing stages was observed. 1. The increase of body weight in the group which started taking the salt water at the latter part of puberty was inverse as the concentration increased. The growth in male was rather less than in female. 2. The increase of body weight in the group which started taking the salt water at the early part of growth completion was also inverse as the concentration increased. In comparison with the former group, however, the degree of ill effects was much less and female growth was somewhat less than male. 3. The administration of the 3 % salt water caused death in all 4 rats. The period up to death was prolonged in the female about twice as in the male. Comparing the two groups, the group starting the experiment at the latter part of puberty died much earlier than the other. 4. Growth of the tail was affected relatively as the concentration increased although there was not much difference in two groups in body weight. Also there was no significant difference between the sexes. 5. Generally speaking, the averaged calory intake per kg. per day was more in the female than the male; but the authors did not observe a meaningful difference between the two groups. The group administered 3 % salt water took particularly fewer calories. 6. The total salt intake per kg. per day was the most in the 3 % salt water administered group and decreased as the concentration was lowered. The LPP group and the female sex took remarkably more salt in comparison. The authors will make another report in the near future as to the biochemical, ecological and pathohistogical observations of the studied rats.
