1986 Volume 17 Issue 4 Pages 577-583
A case of Bartter's syndrome associated with acquired cytomegalovirus (CMV) infection and hydrocephalus was described. A 185 days old boy was admitted to our department for electrolytic disturbances (hypokalemia, hyponatremia, hypochloremia), failure to thrive and progressive ventricuromegaly. He was born at 27 weeks of gestation weighing 1200g. He developed IRDS and was mechanically ventilated for 15 days. No intracranial hemorrahge was found by cranial echography. CMV was cultured in urine at 60 days. Hypokalemia was revealed from 110 days. On admission, his weight was 2150g. Shunt operation was done, however electrolytic disturbances were not improved. Plasma renin activity, aldosterone, angiotensin II were elevated, and metabolic alkalosis was recognized. He was diagnosed as Bartter's syndrome. He was treated with Aldacton-A succsessfully for maintaing serum K without supplement. But at 293 days, he died of purulent meningitis. Renal autopsy specimen showed moderate hyperplasia of the juxtaglomerular cells, tubular hydropic degeneration, and interstitial nephritis.
