1991 Volume 22 Issue 4 Pages 575-583
The effects of systemic administration of IL-1 on bone mineral metabolism were investigated in normal rats which received daily intraperitoneal injections of recombinant human interleukin-1-alpha (rhIL-1α) either 4 μg for 7 days, 2 μg for 7 days or 2 μg for 10 days. Tibial bone histomorphometry revealed significantly increased bone resorption and formation with the loss of bone volume (high turnover bone remodeling) in rhIL-1α 4 μg for 7 days group. In rhIL-1α 2 μg groups, tibial bone histomorphometry revealed significantly increased bone resorption and formation for 10 days, not for 7 days. There were no significant changes in blood ionized calcium levels, serum bone Gla protein and 1,25 dihydroxyvitamin D levels. Serum parathyroid hormone levels in rhIL-1α 4 μg for 7 days group were significantly decreased. These results indicate that IL-1 may affect bone tissue in vivo as well as in vitro so as to cause high turnover bone remodeling.
