1993 Volume 24 Issue 2 Pages 213-222
Effects of acute estrogen deficiency after oophorectomy on lumber bone mineral density (BMD), bone and calcium metabolism were studied. Preoperated (Pre), hysterectomized (HX) and oopho-hysterectomized patients (OOX) were analyzed cross sectionally (Study I) and longitudinally (Study II). In study I (Pre : n=92, HX : n=127, OOX : n=186), lumbar BMD decreased rapidly for 2.5 years after OOX and went to steady state thereafter. In study II (HX: n=43, OOX : n=36), 9.2% and 11.3% decrease in lumbar BMD were found at 1 and 2 years after OOX, respectively. Serum level of osteocalcin as a marker of bone formation kept high level after OOX, while urinary excretions of OH-proline and d-pyridinoline as markers of bone resorption transiently increased and decreased thereafter. In spite of the increase in serum calcium level after OOX, serum PTH level decreased transiently at 1 year after OOX and increased subsequently. In conclusion, the loss of bone mineral density ends at about 2 years after OOX and the changes in calcium regulation may be a causal factor for the termination of bone mineral loss after OOX.
