Abstract
As plasma substitute, gelatin is used clinicaly. Rabbits and guinea pigs do not produce the antibody after administration of gelatin. But the antibody to gelatin in the rabbit and guinea pig can be produced by repeated intrasubcutaneous injection of gelatin with Freund's complete aduvant. The antibody reacts with native gelatin and plasma substitutes. Clinically, we have proved antigelatin-like factor in 1 out of 6 juvenile rheumatoid arthritis but none of 6 patients with arthrosis deformans.
