The difference of pharmacologicl action and side effect between 1314TH and 1321TH, synthetic antitubercular drugs

Abstract

1314TH and 1321TH are both a derviatives of thioseminicotinamide that the former has ethyl group at the position 2 and the other, propyl group at the same position. It has been considered that there are a difference on apperarance of side effects between 1314TH and 1331TH, but recently, it is found the claims that there are not such a difference in those two drugs. As the results of animal experments and clinical investigations, the authors concluded that there are a statistical significant difference between 1314TH and 1321TH on the appearance of nausea and vomiting.