根治手術として喉頭摘出を要した局所進行喉頭・下咽頭扁平上皮癌患者に 対する予後予測における炎症性マーカーの有用性

抄録

To investigate the prognostic significance of the pretreatment inflammatory biomarkers in patients with local advanced laryngeal and hypopharyngeal cancer who received total laryngectomy or laryngopharyngectomy, 32 laryngeal cancer patients and 44 hypopharyngeal cancer patients were enrolled, and the impact of pretreatment inflammatory biomarkers, including fibrinogen, Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and C-reactive protein-to-albumin ratio (CAR) on the survival of these patients were evaluated. These markers were categorized into two groups according to the results of receiver-operating characteristic plots for the determination of the respective cut-off values. In the present study, CAR Ⅳ0.049 was associated with a poor overall survival (OS) and progression-free survival (PFS) in patients with local advanced laryngeal and hypopharyngeal cancer. Our multivariate analysis revealed that CAR Ⅳ0.049 was an independent prognostic factor for the OS and PFS. These results suggested that CAR was a useful pretreatment predictive biomarker for the survival of local advanced laryngeal and hypopharyngeal cancer patients who received total laryngectomy or laryngopharyngectomy.