1989 年 1 巻 1 号 p. 46-51
The etiology of juvenile laryngeal papilloma (JLP) has been suggested to be a viral condition related to the presence of genital warts in the mother at the time of delivery. No direct demonstration of human papilloma virus related to the larynx and genital organ has been established. The incidence of JLP in all areas of Thailand suggests some local endemicity and presents an opportunity to elucidate the etiological bases of this disease. In the current study clinical and virological studies of juvenile laryngeal papilloma were studied in Thai children suffering from the recurrent respiratory papilloma and airway obstruction. Sixty two cases are included in the clinical study and 30biopsy specimens are included in the histopathological and virological examinations. The histological examinations reveal the papillomas were characterized by papillary growth of well differentiated squamous cells with an orderly maturation pattern. No virus particles were demonstrated in the papillomatous tissue sections studied by electron microscopic examination. The DNA dot blot analysis revealed the presence of HPV 11 related sequences in the papillomatous tissue of 6 cases. Clinically, onset was observed before 4 years of age in 80% of the children, and was most frequently observed in first born children. The prevalence of JLP differs in different parts of Thailand. The study does not provide strong support for a viral condition related to the presence of maternal genital warts as the etiological bases for JLP.
