Immunohistochemical Distribution of CD9 in Laryngeal Cancer

Abstract

CD9 is a member of the tetra-membrane-spanning glycoprotein family called tetraspanin. CD9 suppresses breeding and motion in some types of cancer cells. Until presently, the expression of CD9 in the larynx had not yet been elucidated. We examined the expression of CD9 not only in the normal larynx but also in the 25 cases of laryngeal cancer using immunohistochemical staining. CD9 was constantly detected in the normal larynx tissues (epithelium, muscle, cartilage, laryngeal gland and myelin). In contrast, squamous cell carcinoma of the larynx was various stained by antibody to CD9. The five year survival ratio of the CD9 positive group (9 examples) versus the weak positive/negative CD9 group (16 examples) was 88.9% to 82.1%. There was a tendency for immunostaining intensity of laryngeal carcinoma samples to be weak compared to intensities manifested by normal tissues.