アンギオテンシン変換酵素阻害剤の副作用である咳噺が誘因と考えられた喉頭肉芽腫の一例

抄録

A 67-year-old man, who had been treated for hypertension by Angiotensin converting enzyme (ACE) inhibitor therapy for 8 years, complained of difficulties in voice phonation for 3 years. He also complained of dry cough after the administration of ACE inhibitor therapy. Under indirect laryngoscopy, a granuloma with ulceration was observed in the right arytenoid area.
Dry cough was one of the unfavorable side effects of ACE inhibitor therapy, so we thought that the long-lasting dry cough caused the laryngeal granuloma. Then, we changed the prescription from ACE inhibitor to another anti-hypertension drug. Two days later, the dry cough had improved dramatically and the laryngeal granuloma completely disappeared after 16 weeks.