Abstract
Presepsin (P-SEP) is a well-known biomarker for diagnosing sepsis. Although recent reports have demonstrated the usefulness of measuring P-SEP in the blood, there is insufficient evidence in other samples. This study
aimed to explore the clinical usefulness of measuring P-SEP in pleural fluid, ascites, and urine. We used a fully
automated analyzer (STACIA) to measure P-SEP levels and compared P-SEP levels with other clinical data.
Receiver operating characteristic curve analysis, which was used to separate cases of positive culture test using
ascites P-SEP level, showed that the area under the curve was 0.832. The sensitivity and specificity were 94.1%
and 85.7%, respectively, when 1,842 pg/mL of ascites P-SEP was used as the cutoff value. In urine, the P-SEP/
creatinine ratio of patients who showed pyuria was significantly higher than that of the control group. The results
suggest the possible usefulness of P-SEP in ascites and urine, for evaluating local infection.
