Abstract
I produced a miniaturized, multicode, multiband, and programmable light-emitting diode (LED)-
stimulator for the wireless control of optogenetic experiments. The LED-stimulator can drive three
independent LEDs upon reception of an infrared (IR) signal from a newly developed IR-transmitter.
Individual LED photopulse patterns are assigned to as many as 256 different codes of IR signals
generated by the IR-transmitter. Using these devices, I remotely controlled the moving direction of a
Thy1-ChR2-YFP transgenic mouse by transcranially illuminating the corresponding hemisphere of the
primary motor cortex. The IR-transmitter and LED-stimulator will be particularly useful in experiments
where free movements or patterned concurrent stimulations are desired, such as testing the social
communication of rodents. I summarized optogenetics and available wireless photo-stimulators in this
review.
