Abstract
Raman spectroscopy technique, which detects molecular vibration information, determines the chemical
structure of substances. To explore its application possibilities for diagnosing disorders, we applied it
with a ball-lens mounted hollow-fiber Raman probe (BHRP) to detect the differences between control
rats and chronic cystitis model rats that were induced as a first step by the frequent intravesical
administration of hydrochloric acid (a model of bladder pain syndrome/interstitial cystitis, BPS/IC). We
described the difference of bladder conditions between the control and chronic cystitis model animals by
the principal component analysis (PCA) of Raman spectra data. Hence, the Raman technique has
potential as a diagnostic method of chronic cystitis, BPS/IC, or other bladder inflammatory disorders.
