1957 Volume 1 Issue 2 Pages 85-90
A new antiviral antibiotic myxoviromycin, produced by Streptomyces sp., No.E-212, is preliminarily reported. The antibiotic was yielded in a medium consisting of soy bean meal, starch and several inorganic salts. It was purified by an approximately similar procedure as that of streptothricin and obtained in the hydrochloride or the crystalline reineckate. Biological characteristics of myxoviromycin hydrochloride were very unique in the respect that, although the antibiotic was hardly active against many bacteria, fungi and yeast at the concentration of 800 μg/cc or above, it was highly effective in inhibiting the growth of influenza virus in vitro.
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