STUDIES ON ANTIVIRAL ANTIBIOTICS FROM STREPTOMYCES

VI. SEVERAL ACTIVE SUBSTANCES FOUND IN THE COURSE OF SCREENING ANTIBIOTICS AGAINST INFLUENZA VIRUS

Abstract

Four antiviral filtrates were found in the course of screening antiviral antibiotics from streptomyces. Studies were made on the purification procedures of the active agents and on the general properties. All of the active agents belonged to the organic solvent type and showed the same pattern on both summarized and electrophoretic papergrams. However, further studies revealed that they were different from each other. Antibacterial activities of these four substances were chiefly limited to some gram positive bacteria. Toxicity for mice was fairly high except E300. Two antibiotics obtained in crystalline form, F43 and E416, seemed to be new antibiotics.
The authors wish to express their sincere thanks to Prof. M. Kuroya for his kind guidance.