Interferon-Inducing Activity of Acidic Polysaccharides
I. Induction of Rabbit Serum Interferon by Hansenula Phosphomannans
1971 年 15 巻 6 号 p. 485-492
詳細
1971 年 15 巻 6 号 p. 485-492
Exocellular phosphomannans produced by four strains of Hansenula yeast were examined as to their interferon-inducing activities in rabbits employing the assay system consisting of vesicular stomatitis virus and primary suckling rabbit kidney cells. The phosphomannan of Hansenula holstii NRRL Y-2155 was shown to be the most potent inducer, and the interferon induced was highly host species-specific, preventing viral cytopathic effects only in the homologous cells. The biological and chemical characteristics of the interferon closely resembled those of endotoxin-induced interferon.
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