1974 年 18 巻 6 号 p. 457-462
Genetic analyses of the loci conferring resistance to antibiotics known to affect protein synthesis were made employing the conjugation system of Mycobacterium smegmatis. By the complementation tests, vic (viomycin-capreomycin-resistant) mutants were classified into two different groups; cistrons A and B. Neomycin-kanamyein-resistant (nek) mutants, on the contrary, fall into a single cistron. Erythromycin-resistance (ery) locus was linked to vic-nek region. The map order deduced was argB, argA, (vicA, vicB), nek, ery. Biochemical studies showed that strains resistant to streptomycin, neomycinkanamycin or viomycin-capreomycin had altered ribosomes.
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