1958 Volume 2 Issue 1 Pages 89-93
1. Tetracycline was administered orally in relatively small doses to healthy adults and the alteration in the intestinal flora examined both qualitatively and quantitatively. The relation between amounts given and side effects was studied.
2. Continuous administration of tetracycline in relatively small doses (over 500mg daily) results sometimes in the appearance of bacterial alteration. In spite of the decreases of normal flora or bacterial alteration no side effects or symptoms of vitamin deficiency were observed. From these experiments it is believed that the change in intestinal flora following administration of antibiotics does not in itself give rise to side effects or vitamin deficiency.
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