STUDIES ON ANTIVIRAL ANTIBIOTICS FROM STREPTOMYCES

X. EFFECT OF MYXOVIROMYCIN UPON INFECTION WITH INFLUENZA VIRUS IN MICE

Abstract

The effect of myxoviromycin on influenza virus infection in mice was studied. The efficiency of the treatment was chiefly discussed from the view point of the survival rate of mice receiving a dosage of 30-300LD₅₀.
The possibility of a combined therapy of antibiotic and antiserum was investigated and a definite synergistic effect was demonstrated. When the infective dose was 300-3000LD₅₀, an intraperitoneal injection of immune serum immediately after infection and subcutaneous injection of 1mg of myxoviromycin 6 hours after infection completely or partly, at least, protected the mice from the death.