1959 Volume 3 Issue 2 Pages 231-242
The difference in the nature of live vaccine (R type) and killed vaccine im-munizations in experimental typhoid was investigated by observing bacterial multi-plication and host cell response in immunized mice after an intraperitoneal infection with Salmonella enteritidis.
Bacterial multiplication in the spleen was markedly inhibited after the 1st day by the live vaccine immunization, while the infecting organisms in the local body fluid was rapidly killed at the early stage (before 12 hours) in mice immunized with heat-killed vaccine. On the contrary, no inhibition of bacterial multiplication in the spleen after the 1st day was observed in the killed vaccine-immunized mice, nor the decrease in bacterial number in the local body fluid at the early stage in the live vaccine-immunized mice. Inhibition of bacterial multiplication in the pa-renchymal organs of mice seemed to be essential for the protection against mouse typhoid, since the mortality was greatly reduced by the live vaccine immunization.
No marked change in total and differential counts of the locally mobilized cells was observed in mice immunized with the killed vaccine. The host cell response in the live vaccine-immunized mice showed similar tendency to that of the control mice. However, in the former the increase in the number of polymorphonuclear cells was more extensive at an early stage and the ratio between monocytes and polymorphonuclear cells returned to normal more rapidly at later.
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