1960 Volume 4 Issue 2 Pages 105-114
1) According to Okabayashi's intraparanasal sinuses infection method, experiments were successfully performed to produce acute diffuse glomerulonephritis in the kidneys of some rabbits infected with strains of group A hemolytic streptococci. These strains were isolated from the throats of nephritis patients, the confirmed cases of epidemic nephritis in 1955 and 1956.
2) Since the positive cases obtained were only few, any evaluations on the difference of nephritogenic capacities between the two types of streptococci used were not thought to be justified.
Positive cases were obtained by use of type 12 and type 6. However, the most typical case of glomerulonephritis was that infected with type 12, and four out of five cases of early hematuria were also due to type 12 infection. None of the nephritis cases was found in the group infected with each of the standard stock strains of type 12 and type 6.
3) For the apparent establishment of experimental acute glomerulonephritis, some chronic pathologic lesions produced secondarily as metastasis seemed to be necessary besides the primary focus at the paranasal sinuses. It was also clarified that hematuria could be classified, according to the time of occurrence, into an early and a late stage.
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